AICDA

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.

Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity (By similarity).

Probably monoubiquitinated on several residues by RNF126.

Belongs to the cytidine and deoxycytidylate deaminase family.

Expressed in germinal center B-cells (at protein level).

• Nucleus
• Cytoplasm
• Predominantly cytoplasmic. In the presence of MCM3AP/GANP, relocalizes to the nucleus.

Aid, Single-stranded DNA cytosine deaminase, Activation-induced cytidine deaminase, Cytidine aminohydrolase, AID

• swissprot:Q9WVE0

Proteins

Epigenetics