Iba1

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Phosphorylated on serine residues.

Abundantly expressed in the testis, moderately in the spleen and lymph nodes and at low levels in the liver and thymus. Detected in macrophages.

• Cytoplasm
• Cytoskeleton
• Cell projection
• Ruffle membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cell projection
• Phagocytic cup
• Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Iba1, Aif1, Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1

• entrezGene:11629
• swissprot:O70200

Proteins

Neuroscience

16911Da