Iba1

Function

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Post-translational modifications

Phosphorylated on serine residues.

Tissue specificity

Detected in T-lymphocytes and peripheral blood mononuclear cells.

Cellular localization

• Cytoplasm
• Cytoskeleton
• Cell projection
• Ruffle membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cell projection
• Phagocytic cup
• Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

Alternative names

• Allograft inflammatory factor 1
• AIF-1
• Ionized calcium-binding adapter molecule 1
• Protein G1
• IBA1
• G1
• AIF1

Database links

• entrezGene:199
• omim:601833
• swissprot:P55008

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

16703Da