Iba1

Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation.

Phosphorylated on serine residues.

Detected in T-lymphocytes and peripheral blood mononuclear cells.

• Cytoplasm
• Cytoskeleton
• Cell projection
• Ruffle membrane
• Peripheral membrane protein
• Cytoplasmic side
• Cell projection
• Phagocytic cup
• Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.

G1, IBA1, AIF1, Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1

• entrezGene:199
• omim:601833
• swissprot:P55008

Proteins

Neuroscience

16703Da