Aif1
Developmental stage
Expressed early and persistently in chronically rejecting cardiac allografts but is absent in cardiac syngrafts and host hearts. In the embryonic cerebellum, expression peaks at day 7.
Function
Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play an role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity).
Tissue Specificity
Cardiac allograft, spleen and testis. Expressed by inflammatory cells (macrophages and neutrophils).
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell projection
- Ruffle membrane
- Peripheral membrane protein
- Cytoplasmic side
- Cell projection
- Phagocytic cup
- Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis.
Alternative names
Iba1, Mrf1, Aif1, Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, MRF-1, Microglia response factor