AIFM3
Domain
The Rieske domain induces apoptosis.
Function
Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential.
Sequence Similarities
Belongs to the FAD-dependent oxidoreductase family.
Tissue Specificity
Ubiquitous. Expressed in bone marrow, cerebral cortex, liver, ovary, thymus, thyroid gland and tongue (at protein level).
Cellular localization
- Mitochondrion
- Does not translocate to the nucleus upon induction of apoptosis.
Alternative names
AIFL, AIFM3, Apoptosis-inducing factor 3, Apoptosis-inducing factor-like protein