AIG1
Function
Hydrolyzes bioactive fatty-acid esters of hydroxy-fatty acids (FAHFAs), but not other major classes of lipids (PubMed:27018888). Show a preference for FAHFAs with branching distal from the carboxylate head group of the lipids (PubMed:27018888).
Sequence Similarities
Belongs to the AIG1 family.
Tissue Specificity
Highly expressed in heart, ovary, testis, liver, and kidney, at lower levels in spleen, prostate, brain, skeletal muscle, pancreas, small intestine and colon, and undetected in peripheral blood leukocytes, thymus, lung and placenta. AIG1 expression is higher in hair follicles from males than from females.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
CGI-103, AIG1, Androgen-induced gene 1 protein, AIG-1, Fatty acid esters of hydroxy fatty acids hydrolase AIG1, FAHFA hydrolase AIG1