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AIP

Function

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.

Cellular negative regulator of the hepatitis B virus (HBV) X protein.

Involvement in disease

Pituitary adenoma 1, multiple types

PITA1

A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported.

None

The disease is caused by variants affecting the gene represented in this entry.

Prolactin-secreting pituitary adenoma

PSPA

Most common type of hormonally active pituitary adenoma.

None

The disease is caused by variants affecting the gene represented in this entry.

Tissue specificity

Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Cellular localization

  • Cytoplasm

Alternative names

  • AH receptor-interacting protein
  • AIP
  • Aryl-hydrocarbon receptor-interacting protein
  • HBV X-associated protein 2
  • Immunophilin homolog ARA9
  • XAP-2
  • XAP2
  • AIP

Target type

Proteins

Molecular weight

37636Da