AKAP4
Developmental stage
Post-meiotic phase of spermatogenesis.
Domain
RI-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Function
Major structural component of sperm fibrous sheath (PubMed:9822690). Plays a role in sperm motility (PubMed:34415320, PubMed:9822690).
Involvement in disease
Spermatogenic failure (PubMed:34415320, PubMed:38050179). A male infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia (PubMed:34415320, PubMed:38050179). The disease is caused by variants affecting the gene represented in this entry (PubMed:34415320, PubMed:38050179).
Post-translational modifications
Phosphorylated by STK33 during sperm flagella assembly.
Sequence Similarities
Belongs to the AKAP110 family.
Tissue Specificity
Testis specific; only expressed in round spermatids.
Cellular localization
- Cell projection
- Cilium
- Flagellum
- Localizes to the principle piece of the sperm flagellum.
Alternative names
AKAP82, AKAP4, A-kinase anchor protein 4, AKAP-4, A-kinase anchor protein 82 kDa, Major sperm fibrous sheath protein, Protein kinase A-anchoring protein 4, AKAP 82, hAKAP82, HI, PRKA4