AKAP6
Domain
RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.
Function
Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.
Tissue Specificity
Highly expressed in cardiac and skeletal muscle, followed by brain.
Cellular localization
- Sarcoplasmic reticulum
- Nucleus membrane
- In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.
Alternative names
AKAP100, KIAA0311, AKAP6, A-kinase anchor protein 6, AKAP-6, A-kinase anchor protein 100 kDa, Protein kinase A-anchoring protein 6, mAKAP, AKAP 100, PRKA6