AKAP7

Function

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

Tissue Specificity

Expressed in brain, heart, lung, pancreas and skeletal muscle.

Cellular localization

• Isoform Alpha
• Lateral cell membrane
• Lipid-anchor
• Targeted predominantly to the lateral membrane.
• Isoform Beta
• Apical cell membrane
• Lipid-anchor
• Targeted predominantly to the apical membrane.

Alternative names

AKAP15, AKAP18, AKAP7, A-kinase anchor protein 7 isoforms alpha and beta, AKAP-7 isoforms alpha and beta, A-kinase anchor protein 18 kDa, Protein kinase A-anchoring protein 7 isoforms alpha/beta, AKAP 18, PRKA7 isoforms alpha/beta

Database links

swissprot:O43687 entrezGene:9465 swissprot:Q9P0M2 omim:604693