AKIRIN1
Function
Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (By similarity). Functions as a signal transducer for MSTN during skeletal muscle regeneration and myogenesis (By similarity). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (By similarity). In contrast to AKIRIN2, not involved in nuclear import of proteasomes (PubMed:34711951).
Sequence Similarities
Belongs to the akirin family.
Tissue Specificity
Widely expressed with the highest expression in heart, liver, placenta and peripheral blood leukocytes.
Cellular localization
- Nucleus
Alternative names
C1orf108, AKIRIN1, Akirin-1