AKR7A3
Function
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Sequence Similarities
Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.
Tissue Specificity
Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium.
Cellular localization
- Cytoplasm
Alternative names
AFAR2, AKR7A3, Aflatoxin B1 aldehyde reductase member 3, AFB1 aldehyde reductase 2, AFB1-AR 2