Expressed both maternally and zygotically. Strongly expressed in embryo and pupa. Weakly expressed in larva. Mildly expressed in adult.
Binding of the PH domain to the phosphatidylinositol 3-kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
Serine/threonine kinase involved in various developmental processes (PubMed:10587646, PubMed:10962553, PubMed:11740943, PubMed:11872800, PubMed:12172554, PubMed:12893776, PubMed:14525946, PubMed:15466161, PubMed:15712201, PubMed:9601646). During early embryogenesis, acts as a survival protein (PubMed:10962553, PubMed:9601646). During mid-embryogenesis, phosphorylates and activates trh, a transcription factor required for tracheal cell fate determination (PubMed:11740943). Also regulates tracheal cell migration (PubMed:11740943, PubMed:14525946). Later in development, acts downstream of PI3K and Pk61C/PDK1 in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and antagonizing FOXO transcription factor (PubMed:10587646, PubMed:10962553, PubMed:11752451, PubMed:12893776, PubMed:24603715, PubMed:25329475, PubMed:29025897). Controls follicle cell size during oogenesis (PubMed:15712201). May also stimulate cell growth by phosphorylating Gig/Tsc2 and inactivating the Tsc complex (PubMed:12172554, PubMed:15466161). Dephosphorylation of 'Ser-586' by Phlpp triggers apoptosis and suppression of tumor growth (PubMed:10962553).
Phosphorylated and activated by Pk61C/PDK1 (PubMed:11344272). Phosphorylated on Ser-586 by the TORC2 complex (PubMed:10962553, PubMed:15718470, PubMed:22493059).
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
Ubiquitously expressed. Present in ovary, where it is concentrated at the basal side of follicle cells.
Proteins
68485Da
We found 1 product in 1 category