AKT1S1

The TOS motif mediates interaction with RPTOR, leading to promote phosphorylation by mTORC1 complex.

Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (By similarity). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate-recruitment site (By similarity). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (By similarity). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (By similarity). May also play a role in nerve growth factor-mediated neuroprotection (PubMed:14973226, PubMed:16397181).

Phosphorylated by AKT1; phosphorylation takes place in response to insulin treatment and promotes AKT1S1 interaction with 14-3-3 proteins, leading to relieve its inhibitor activity (By similarity). Phosphorylated by MTOR following mTORC1 activation, inhibiting AKT1S1 inhibitor activity: phosphorylation by MTOR probably serves as a feedback loop that relieves inhibition from AKT1S1 in response to mTORC1 inactivation (By similarity). Phosphorylation at Thr-247 by DYRK3 relieves inhibitory function on mTORC1 (By similarity).

• Cytoplasm
• Cytosol
• Found in the cytosolic fraction of the brain (PubMed:14973226). Colocalizes with cortical neurons following ischemic/reperfusion injury (PubMed:14973226).

Pras, Akt1s1, Proline-rich AKT1 substrate 1, Proline-rich AKT substrate

• entrezGene:67605
• swissprot:Q9D1F4

Proteins

Oncology

27483Da