Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage.
Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1.
Belongs to the aldehyde dehydrogenase family.
Ahd-1, Ahd1, Aldh2, AHD-M1, ALDH class 2, ALDH-E2, ALDHI
Proteins
Metabolism
56538Da
We found 1 product in 1 category