ALDH3A1

Function

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde (Probable). They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (Probable). Oxidizes medium and long chain aldehydes into non-toxic fatty acids (PubMed:1737758). Preferentially oxidizes aromatic aldehyde substrates (PubMed:1737758). Comprises about 50 percent of corneal epithelial soluble proteins (By similarity). May play a role in preventing corneal damage caused by ultraviolet light (By similarity).

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Tissue specificity

High levels in stomach, esophagus and lung; low level in the liver and kidney.

Cellular localization

• Cytoplasm

Alternative names

• ALDHIII
• Aldehyde dehydrogenase 3
• Aldehyde dehydrogenase family 3 member A1
• ALDH3
• ALDH3A1

Database links

• entrezGene:218
• omim:100660
• swissprot:P30838

Target type

Proteins

Molecular weight

50395Da