ALDH3B1

Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:23721920). May have a protective role against the cytotoxicity induced by lipid peroxidation (PubMed:17382292). Short-chain fatty aldehydes are not good substrates (PubMed:17382292). Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels (PubMed:17382292). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (PubMed:17382292, PubMed:23721920). Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form (PubMed:17382292).

Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.

Belongs to the aldehyde dehydrogenase family.

Highest expression in kidney and lung.

• Cell membrane
• Lipid-anchor
• Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.

ALDH7, ALDH3B1, Aldehyde dehydrogenase family 3 member B1, Aldehyde dehydrogenase 7, Long-chain fatty aldehyde dehydrogenase, Medium-chain fatty aldehyde dehydrogenase

• entrezGene:221
• omim:600466
• swissprot:P43353

Proteins

Oncology

51840Da