ALDOA
GeneName
ALDOA
Summary
ALDOA, also known as aldolase or ALDA, is a 39kDa enzyme predominantly expressed in muscle and brain tissues. It is a member of the fructose-bisphosphate aldolase family and plays a crucial role in glycolysis, catalysing the reversible conversion of fructose 1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. ALDOA is localised in various cellular compartments, including the cytosol, actin cytoskeleton, and myofibrils, and is involved in actin filament organisation and muscle contraction. Additionally, it has binding capabilities for fructose, RNA, and tubulin, linking it to various cellular processes.
Importance
ALDOA is relevant to: - Energy metabolism and glycolysis, which are essential for cellular respiration and ATP production - Muscle physiology, particularly in striated muscle contraction and maintaining muscle cell homeostasis - Sperm function, as it plays a role in the binding of sperm to the zona pellucida - Potential metabolic disorders, given its involvement in fructose metabolism and glycolytic pathways
Top Products
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Abcam Product Citation Summary
The data indicates that ALDOA is being studied in the context of aerobic glycolysis, particularly in human MGC-803 cells. This suggests a focus on metabolic pathways and their implications in cellular processes.
Abcam Product Citation Table
Function
Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, may also function as scaffolding protein (By similarity).
Involvement in disease
Glycogen storage disease 12
GSD12
A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
None
The disease is caused by variants affecting the gene represented in this entry.
Pathway
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
Post-translational modifications
Phosphorylated at Ser-39 in response to beta-arrestin-1 (ARRB1) signaling, promoting the fructose-bisphosphate aldolase activity, leading to enhanced glycolysis and improved glucose tolerance.
Sequence Similarities
Belongs to the class I fructose-bisphosphate aldolase family.
Cellular localization
- Cytoplasm
- Myofibril
- Sarcomere
- I band
- Cytoplasm
- Myofibril
- Sarcomere
- M line
- In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+).
Alternative names
ALDA, ALDOA, Fructose-bisphosphate aldolase A, Lung cancer antigen NY-LU-1, Muscle-type aldolase