ALKBH4
Function
Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (PubMed:23673617). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (PubMed:23673617). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (By similarity).
Sequence Similarities
Belongs to the alkB family.
Tissue Specificity
Widely expressed, with highest expression in pancreas, ovary and spleen.
Cellular localization
- Cytoplasm
- Nucleus
- Nucleus
- Nucleolus
- Midbody
- Associates with the contractile ring and midbody.
Alternative names
ABH4, ALKBH4, Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4, Alkylated DNA repair protein alkB homolog 4, DNA N6-methyl adenine demethylase ALKBH4, Lysine-specific demethylase ALKBH4