ALKBH7
Function
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).
Sequence Similarities
Belongs to the alkB family.
Tissue Specificity
Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
Cellular localization
- Mitochondrion matrix
Alternative names
ABH7, SPATA11, UNQ6002/PRO34564, ALKBH7, Alkylated DNA repair protein alkB homolog 7, Spermatogenesis cell proliferation-related protein, Spermatogenesis-associated protein 11