AMELX
Developmental stage
Transiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is the predominant protein in developing dental enamel.
Function
Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.
Involvement in disease
Amelogenesis imperfecta 1E
AI1E
An X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylated by FAM20C in vitro.
Sequence Similarities
Belongs to the amelogenin family.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
AMG, AMGX, AMELX