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AMH
Function
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
Involvement in disease
Persistent Muellerian duct syndrome 1
PMDS1
A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence similarities
Belongs to the TGF-beta family.
Cellular localization
- Secreted
Alternative names
- Muellerian-inhibiting factor
- Anti-Muellerian hormone
- Muellerian-inhibiting substance
- AMH
- MIS
- MIF
- AMH
Database links
Target type
Proteins
Molecular weight
59195Da