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AMH
Function
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
Sequence similarities
Belongs to the TGF-beta family.
Tissue specificity
Sertoli cells of fetal testes, and testes just after birth, but absent in adult testes. In female, AMH is expressed after birth in the granulosa cells of the follicle. AMH expression is dependent on the degree of follicular maturation and not on the age of the ovary.
Cellular localization
- Secreted
Alternative names
- Muellerian-inhibiting factor
- Anti-Muellerian hormone
- Muellerian-inhibiting substance
- AMH
- MIS
- Amh
Database links
Target type
Proteins
Molecular weight
59778Da