AMOT
Domain
The coiled coil domain interacts directly with the BAR domain of ARHGAP17.
The angiostatin binding domain (871-1005) allows the binding to angiostatin.
Function
Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (PubMed:21205866).
Post-translational modifications
Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation.
Sequence Similarities
Belongs to the angiomotin family.
Tissue Specificity
Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
Cellular localization
- Cell junction
- Tight junction
- Localized on the cell surface. May act as a transmembrane protein.
Alternative names
KIAA1071, AMOT, Angiomotin