AMTN
Function
Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis.
Involvement in disease
Amelogenesis imperfecta 3B
AI3B
An autosomal dominant form of amelogenesis imperfecta, a defect of enamel formation. AI3B is characterized by hypomineralized enamel that has reduced tickness and exhibits structural defects.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Phosphorylated by FAM20C in vitro.
O-glycosylated.
Sequence Similarities
Belongs to the amelotin family.
Cellular localization
- Secreted
Alternative names
UNQ689/PRO1329, AMTN, Amelotin