Angiomotin-like protein 1

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.

Polyubiquitinated by NEDD4, leading to proteasomal degradation.

Belongs to the angiomotin family.

• Cell junction
• Tight junction

Angiomotin-like protein 1, AMOTL1

• entrezGene:154810
• omim:614657
• swissprot:Q8IY63

Proteins

Oncology

106574Da