Angiomotin-like protein 1
Function
Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.
Post-translational modifications
Polyubiquitinated by NEDD4, leading to proteasomal degradation.
Sequence Similarities
Belongs to the angiomotin family.
Cellular localization
- Cell junction
- Tight junction
Alternative names
Angiomotin-like protein 1, AMOTL1