Angiopoietin-1

Function

Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.

Cellular localization

• Secreted

Alternative names

Angiopoietin-1, ANG-1, Angpt1

Database links

swissprot:O35460 entrezGene:89805 swissprot:O35462 swissprot:89807