ANGPT1
GeneName
ANGPT1
Summary
ANGPT1, also known as Ang-1 or angiopoietin-1, is a 58 kDa secreted protein that plays a vital role in angiogenesis and vascular development. It is primarily expressed in endothelial cells and is found in various extracellular components, including the extracellular matrix and plasma membrane. ANGPT1 functions as a ligand for the Tie2 receptor, activating transmembrane receptor protein tyrosine kinase activity, which is essential for promoting blood vessel stability and regulating vascular permeability. Additionally, it is involved in processes such as blood coagulation, cell-substrate adhesion, and negative regulation of apoptotic processes in various cell types.
Importance
ANGPT1 is relevant to: - Angiogenesis and vascular development, influencing blood vessel formation and stability - Regulation of vascular permeability, which is crucial in inflammatory responses and tissue homeostasis - Blood coagulation processes, impacting wound healing and tissue repair - Modulation of immune responses through its effects on cytokine production and macrophage migration - Potential therapeutic target in diseases characterised by abnormal angiogenesis, such as cancer and diabetic retinopathy
Top Products
For researchers investigating ANGPT1, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-Angiopoietin 1 antibody (ab8451), which has garnered 64 citations, reflecting its reliability in the field. This antibody is particularly effective for Western blotting (WB) and immunohistochemistry (IHC), making it a versatile choice for various applications. Additionally, we offer the recombinant antibody, Anti-Angiopoietin 1 antibody [EPR2888(N)] (ab183701), which is validated for use in Western blotting (WB) and has 28 citations. This recombinant product ensures batch-to-batch consistency, providing researchers with a dependable option for ANGPT1 detection. Together, these antibodies represent a robust toolkit for studying ANGPT1 in your research. The Anti-Angiopoietin 1 antibody [EPR2889(N)] ELISA Kit (ab183702) is a reliable option for researchers looking to measure ANGPT1 levels in their samples.
Abcam Product Citation Summary
The data indicates that ANGPT1 is being studied in various contexts, particularly in relation to angiogenesis and endothelial cell function. The use of Abcam antibodies in human glioblastoma cultures and umbilical vein endothelial cells highlights the relevance of ANGPT1 in cancer and vascular biology. Additionally, the measurement of ANGPT1 in different cell types suggests its potential role in various physiological and pathological processes.
Abcam Product Citation Table
Function
Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Involvement in disease
Angioedema, hereditary, 5
HAE5
A form of angioedema, a disorder characterized by episodic local swelling involving subcutaneous or submucous tissue of the upper respiratory and gastrointestinal tracts, face, extremities, and genitalia. HAE5 is an autosomal dominant form characterized by onset of episodic swelling of the face, lips, hands, and abdomen in the second decade of life.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Glycosylated.
Cellular localization
- Secreted
Alternative names
KIAA0003, ANGPT1, Angiopoietin-1, ANG-1
Database links
swissprot:Q15389 omim:601667 entrezGene:284
Other research areas
- Oncology