ANGPT2
GeneName
ANGPT2
Summary
ANGPT2, also known as Ang2 or angiopoietin-2, is a 57kDa secreted protein that plays a significant role in angiogenesis and vascular remodelling. It is primarily expressed in the extracellular region and is involved in various biological processes including blood coagulation and the response to growth factors. ANGPT2 functions as a ligand for receptor tyrosine kinases, particularly the Tie receptor family, and is implicated in both the positive and negative regulation of angiogenesis and endothelial cell migration. This dual role in angiogenesis makes it a critical player in both promoting and inhibiting blood vessel formation, depending on the context.
Importance
ANGPT2 is relevant to: - Tumour biology, as it influences angiogenesis and the tumour microenvironment, affecting tumour growth and metastasis - Vascular diseases, due to its involvement in blood vessel formation and stability - Regenerative medicine, given its role in animal organ regeneration and tissue repair processes - Pregnancy-related research, as it participates in maternal processes and may impact placental development and function
Top Products
For researchers investigating ANGPT2, we highly recommend the top-selling recombinant antibody, Anti-Angiopoietin 2/ANG2 antibody [EPR2891(2)] (ab155106). This antibody has been validated for use in Western blotting (WB) and has garnered 46 citations, reflecting its reliability and acceptance in the scientific community. Its recombinant nature ensures batch-to-batch consistency, making it an excellent choice for those requiring dependable ANGPT2 detection in their experiments. The Anti-Angiopoietin 2/ANG2 antibody ELISA Kit (ab155106), supported by 46 citations, is an excellent option for researchers looking to accurately measure ANGPT2 levels in their samples.
Abcam Product Citation Summary
The data indicates that ANGPT2 is being studied in various biological contexts, particularly in rat tissues such as endometrium and retinas, as well as in Rhesus Monkey placenta. The use of both Western blotting and immunohistochemistry-immunofluorescence suggests a focus on protein expression and localisation in these tissues.
Abcam Product Citation Table
Domain
The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.
Function
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Involved in the regulation of lymphangiogenesis (PubMed:32908006).
Involvement in disease
Lymphatic malformation 10
LMPHM10
A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Patients with lymphedema may suffer from recurrent local infections. LMPHM10 is an autosomal dominant form characterized by the onset of swelling in the lower extremities within the first year of life. Lymphedema may also occur in the neck, upper extremities, and scrotum or labia majora. Gradual resorption generally occurs, although some patients may experience progression complicated by cellulitis. Incomplete penetrance has been observed in some families.
None
The disease is caused by variants affecting the gene represented in this entry.
Cellular localization
- Secreted
Alternative names
Angiopoietin-2, ANG-2, ANGPT2
Database links
swissprot:O15123 entrezGene:285 omim:601922
Other research areas
- Oncology