Angpt2

Domain

The Fibrinogen C-terminal domain mediates interaction with the TEK/TIE2 receptor.

Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (By similarity). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (By similarity). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression (By similarity). In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis (PubMed:28179430, PubMed:32908006).

Tissue Specificity

Expressed in the ovary, uterus and placenta.

Cellular localization

• Secreted

Alternative names

Agpt2, Angpt2, Angiopoietin-2, ANG-2

Database links

swissprot:O35608 entrezGene:11601

Other research areas

• Oncology