ANGPT4
Function
Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.
Tissue Specificity
Highly expressed in the lung with much lower levels found in other tissues.
Cellular localization
- Secreted
Alternative names
ANG3, ANG4, ANGPT4, Angiopoietin-4, ANG-4, Angiopoietin-3, ANG-3