ANKFY1
Function
Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport.
Tissue Specificity
High expression in whole adult brain and intermediate expression in all other tissues and specific brain regions examined, including fetal brain.
Cellular localization
- Cytoplasm
- Endosome membrane
- Peripheral membrane protein
- Early endosome
- Also associated with endosomal membranes. Localizes to macropinosomes.
Alternative names
ANKHZN, KIAA1255, ANKFY1, Rabankyrin-5, Rank-5, Ankyrin repeat and FYVE domain-containing protein 1, Ankyrin repeats hooked to a zinc finger motif