ANKLE1
Developmental stage
Expressed in fetal spleen, liver and thymus.
Domain
The LEM domain is required for GIY-YIG domain-mediated DNA cleavage and induction of DNA damage response.
Function
Endonuclease that probably plays a role in the DNA damage response and DNA repair.
Tissue Specificity
Expression is predominant in adult bone marrow.
Cellular localization
- Cytoplasm
- Nucleus
- At the steady state, localizes predominantly in the cytoplasm.
Alternative names
ANKRD41, LEM3, ANKLE1, Ankyrin repeat and LEM domain-containing protein 1, Ankyrin repeat domain-containing protein 41, LEM-domain containing protein 3