ANKRA2
Domain
The ankyrin repeats, mainly ANK 2, ANK 3 and ANK 4, mediate interaction with a wide array of PxLPxI/L motif-containing proteins including HDAC4 and LRP2. The PxLPxI/L motif of interactors can contain a Ser or a Thr residue in position 2, which phosphorylation prevents the interaction with ANKRA2.
Function
May regulate the interaction between the 3M complex and the histone deacetylases HDAC4 and HDAC5 (PubMed:25752541). May also regulate LRP2/megalin (By similarity).
Cellular localization
- Cytoplasm
- Cytoskeleton
- Membrane
- Peripheral membrane protein
Alternative names
ANKRA, ANKRA2, Ankyrin repeat family A protein 2, RFXANK-like protein 2