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Annexin A5

Domain

The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Function

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

Involvement in disease

Pregnancy loss, recurrent, 3

RPRGL3

A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Post-translational modifications

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.

Sequence similarities

Belongs to the annexin family.

Alternative names

  • ANX5
  • ENX2
  • PP4
  • ANXA5
  • ANX5
  • ENX2
  • PP4
  • Annexin A5
  • Anchorin CII
  • Annexin V
  • Annexin-5
  • Calphobindin I
  • Endonexin II
  • Lipocortin V
  • Placental anticoagulant protein 4
  • Placental anticoagulant protein I
  • Thromboplastin inhibitor
  • Vascular anticoagulant-alpha
  • CPB-I
  • PP4
  • PAP-I
  • VAC-alpha

Target type

Proteins

Primary research area

Oncology

Molecular weight

35937Da