ANO2
Function
Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.
Sequence Similarities
Belongs to the anoctamin family.
Tissue Specificity
Retina, especially in the photoreceptor synaptic terminals.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
C12orf3, TMEM16B, ANO2, Anoctamin-2, Transmembrane protein 16B