Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
(Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.
Scott syndrome
SCTS
A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents.
None
The disease is caused by variants affecting the gene represented in this entry.
Belongs to the anoctamin family.
Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.
TMEM16F, ANO6, Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, Transmembrane protein 16F, SCAN channel
Proteins
Oncology
106165Da
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