Ano6
Developmental stage
At 14.5 dpc, expressed in lung epithelium and mesenchyme. At 16.5 dpc, expressed in esophageal epithelium and mesenchyme. In the caudal digestive tract, detected in small intestine epithelium at 14.5 dpc. Also detected at 14.5 dpc in epithelium and mesenchyme of trachea, ovary, kidney and stomach. In the developing skeleton, expressed in developing rib perichondria at 14.5 dpc. Also expressed in the neural tube and dorsal root ganglia at 14.5 dpc. In developing skin, expression is restricted to basal layers of the epidermis at 16.5 dpc.
Function
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Sequence Similarities
Belongs to the anoctamin family.
Tissue Specificity
Predominant expression seen in epithelial tissues. Also found in skeletal system where it is primarily expressed in osteoblasts.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Shows an intracellular localization.
Alternative names
Tmem16f, Ano6, Anoctamin-6, Small-conductance calcium-activated nonselective cation channel, Transmembrane protein 16F, SCAN channel