ANO7
Function
Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a role in cell-cell interactions (PubMed:17308099).
Sequence Similarities
Belongs to the anoctamin family.
Tissue Specificity
Specifically expressed in epithelial cells of the prostate (at protein level).
Cellular localization
- Isoform 1
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- Endoplasmic reticulum
- Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604.
- Isoform 2
- Cytoplasm
- Cytosol
Alternative names
NGEP, PCANAP5, TMEM16G, ANO7, Anoctamin-7, Dresden transmembrane protein of the prostate, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G, D-TMPP