Anoctamin 7

Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a role in cell-cell interactions (PubMed:17308099).

Belongs to the anoctamin family.

Specifically expressed in epithelial cells of the prostate (at protein level).

• Isoform 1
• Cell membrane
• Multi-pass membrane protein
• Cell junction
• Endoplasmic reticulum
• Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604.
• Isoform 2
• Cytoplasm
• Cytosol

NGEP, PCANAP5, TMEM16G, ANO7, Anoctamin-7, Dresden transmembrane protein of the prostate, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G, D-TMPP

• entrezGene:50636
• omim:605096
• swissprot:Q6IWH7

Proteins

Cardiovascular

105532Da