ANO9
Function
PKA-activated nonselective cation channel (PubMed:29604966). Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations (By similarity). Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store (PubMed:36520003). Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue (PubMed:36520003). Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22178883). Can inhibit the activity of ANO1 (PubMed:20056604, PubMed:22946059).
Post-translational modifications
Phosphorylated on serine residues by cAMP-dependent protein kinase A (PKA) which is essential for activation of its cation channel activity.
Sequence Similarities
Belongs to the anoctamin family.
Tissue Specificity
Expressed in the kidney (PubMed:36520003). Expressed in the olfactory epithelium (PubMed:36330924).
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Endoplasmic reticulum
- Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Alternative names
PIG5, TMEM16J, TP53I5, ANO9, Anoctamin-9, Transmembrane protein 16J, Tumor protein p53-inducible protein 5, p53-induced gene 5 protein