ANPEP

Function

Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).

(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.

(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.

Post-translational modifications

Sulfated.

N- and O-glycosylated.

May undergo proteolysis and give rise to a soluble form.

Sequence similarities

Belongs to the peptidase M1 family.

Tissue specificity

Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.

Cellular localization

• Cell membrane
• Single-pass type II membrane protein
• Also found as a soluble form.

Alternative names

• Aminopeptidase N
• AP-N
• hAPN
• Alanyl aminopeptidase
• Aminopeptidase M
• Microsomal aminopeptidase
• Myeloid plasma membrane glycoprotein CD13
• gp150
• AP-M
• APN
• ANPEP
• CD13
• PEPN

Database links

• entrezGene:290
• entrezGene:929
• omim:158120
• omim:151530
• swissprot:P15144
• swissprot:P08571

Target type

Proteins

Molecular weight

109540Da