ANPEP
GeneName
ANPEP
Summary
ANPEP, also known as gp130, APN, or CD13, is a 110 kDa type II membrane protein that is expressed in various tissues, including the kidney, lung, and heart. It is localised to the plasma membrane and other cellular compartments such as the cytoplasm and endoplasmic reticulum-Golgi intermediate compartment. ANPEP functions primarily as an alanyl aminopeptidase, involved in the cleavage of amino acids from the N-terminus of peptides. It also plays a role in peptide binding and is implicated in several biological processes, including angiogenesis, cell differentiation, and proteolysis. Additionally, ANPEP acts as a receptor for certain viruses, highlighting its importance in host-pathogen interactions.
Importance
ANPEP is relevant to: - Angiogenesis and tissue remodelling, impacting wound healing and tumour growth - Regulation of blood pressure through its role in angiotensin maturation - Immune responses, as it influences cell differentiation and peptide catabolism - Viral pathogenesis, given its function as a receptor for specific viruses
Top Products
For researchers investigating ANPEP, we highly recommend the top-selling recombinant antibody, Anti-CD13 antibody [EPR4058] (ab108310). This antibody has been validated in knockout models, ensuring its reliability in various applications, including immunohistochemistry (IHC), western blotting (WB), and immunocytochemistry (ICC). With 36 citations, it is well-regarded in the research community, making it an excellent choice for those seeking dependable ANPEP detection. The Human CD13 ELISA Kit (ab239427), supported by 1 citation, is an excellent option for researchers looking to measure ANPEP levels in their samples.
Abcam Product Citation Summary
The data indicates that ANPEP is being studied in the context of liver cancer stem cells and cell differentiation, particularly in human and mouse models. The use of various applications such as Western blot and immunofluorescence highlights the importance of ANPEP in understanding resistance mechanisms in cancer and the differentiation processes of stem cells.
Abcam Product Citation Table
Function
Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity).
(Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein.
(Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
Post-translational modifications
Sulfated.
N- and O-glycosylated.
May undergo proteolysis and give rise to a soluble form.
Sequence Similarities
Belongs to the peptidase M1 family.
Tissue Specificity
Expressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
- Also found as a soluble form.
Alternative names
CD13, APN, PEPN, ANPEP, Aminopeptidase N, AP-N, hAPN, Alanyl aminopeptidase, Aminopeptidase M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, AP-M
Database links
swissprot:P15144 entrezGene:290 entrezGene:929 swissprot:P08571 omim:158120 omim:151530