ANXA13
Domain
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function
Isoform A
Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner (PubMed:27676605, PubMed:30610115). Half-maximal membrane binding requires about 60 uM calcium. Does not bind to membranes that lack phospholipids with an acidic headgroup (PubMed:27676605).
Isoform B
Binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, but requires higher calcium levels for membrane binding than isoform A. Half-maximal membrane binding requires about 320 uM calcium.
Sequence Similarities
Belongs to the annexin family.
Tissue Specificity
Detected in epithelial cells in colon and jejunum (at protein level). Detected in epithelial cells in jejunum.
Cellular localization
- Apical cell membrane
- Cell membrane
- Lipid-anchor
- Cytoplasmic vesicle
- Myristoylation anchors the protein to the membrane, but the protein also displays calcium-dependent, reversible binding to lipid membranes (PubMed:30610115). Associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes (PubMed:1530946).
Alternative names
ANX13, ANXA13, Annexin A13, Annexin XIII, Annexin-13, Intestine-specific annexin, ISA