ANXA2 phospho S26
Domain
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:18799458, PubMed:22848640, PubMed:24808179).
(Microbial infection) Binds M.pneumoniae CARDS toxin, probably serves as one receptor for this pathogen. When ANXA2 is down-regulated by siRNA, less toxin binds to human cells and less vacuolization (a symptom of M.pneumoniae infection) is seen.
Involvement in disease
Increased expression of ANXA2 is associated with hepatocellular carcinoma tumor progression.
Post-translational modifications
Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface.
ISGylated.
Sequence Similarities
Belongs to the annexin family.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Basement membrane
- Melanosome
- In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism.
Alternative names
ANX2, ANX2L4, CAL1H, LPC2D, ANXA2, Annexin A2, Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein IV, Protein I, p36, PAP-IV