Anxa2
Domain
A pair of annexin repeats may form one binding site for calcium and phospholipid.
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:22848640).
Post-translational modifications
ISGylated.
Sequence Similarities
Belongs to the annexin family.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
- Basement membrane
- Melanosome
- In the lamina beneath the plasma membrane.
Alternative names
Anx2, Cal1h, Anxa2, Annexin A2, Annexin II, Annexin-2, Calpactin I heavy chain, Calpactin-1 heavy chain, Chromobindin-8, Lipocortin II, Placental anticoagulant protein IV, Protein I, p36, PAP-IV