AOAH
Function
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:29343645, PubMed:8089145). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (By similarity). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria (By similarity).
Post-translational modifications
Cleaved into a large and a small subunit.
The small subunit is N-glycosylated.
Cellular localization
- Secreted
- Cytoplasmic vesicle
- Detected in urine.
Alternative names
Acyloxyacyl hydrolase, AOAH