Aoc1
Function
Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates in vitro are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes.
Post-translational modifications
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
N-glycosylated.
Sequence Similarities
Belongs to the copper/topaquinone oxidase family.
Cellular localization
- Secreted
- Extracellular space
- Cell membrane
- Peripheral membrane protein
- Extracellular side
Alternative names
Abp1, Aoc1, Diamine oxidase [copper-containing], Diamine oxidase, Amine oxidase copper domain-containing protein 1, Histaminase