Aoc3
Function
Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Has a preference for the primary monoamines methylamine and benzylamine (PubMed:15744061). Could also act on 2-phenylethylamine but much less efficiently. At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion (By similarity).
Post-translational modifications
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
N- and O-glycosylated.
Sequence Similarities
Belongs to the copper/topaquinone oxidase family.
Tissue Specificity
Highly expressed in adipocytes, aorta and lung. Expressed at lower levels in heart, kidney, large intestine, liver, small intestine and stomach.
Cellular localization
- Cell membrane
- Single-pass type II membrane protein
Alternative names
Amine oxidase [copper-containing] 3, Amine oxidase copper-containing 3, Copper amine oxidase, Semicarbazide-sensitive amine oxidase, VP97, Vascular adhesion protein 1, SSAO, VAP-1