AP1AR
Function
Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.
Post-translational modifications
Palmitoylated.
Cellular localization
- Golgi apparatus
- trans-Golgi network
- Late endosome
- Early endosome
- Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.
Alternative names
C4orf16, PRO0971, AP1AR, AP-1 complex-associated regulatory protein, 2c18, Adaptor-related protein complex 1-associated regulatory protein, Gamma-1-adaptin brefeldin A resistance protein, Gamma-A1-adaptin and kinesin interactor, GBAR, Gamma-BAR, Gadkin