AP1M1
Function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
Post-translational modifications
Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.
Sequence Similarities
Belongs to the adaptor complexes medium subunit family.
Cellular localization
- Golgi apparatus
- Cytoplasmic vesicle
- Clathrin-coated vesicle membrane
- Peripheral membrane protein
- Cytoplasmic side
- Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Alternative names
CLTNM, AP1M1, AP-1 complex subunit mu-1, AP-mu chain family member mu1A, Adaptor protein complex AP-1 subunit mu-1, Adaptor-related protein complex 1 subunit mu-1, Clathrin assembly protein complex 1 mu-1 medium chain 1, Clathrin coat assembly protein AP47, Clathrin coat-associated protein AP47, Golgi adaptor HA1/AP1 adaptin mu-1 subunit, Mu-adaptin 1, Mu1A-adaptin