AP3S1
Function
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.
Sequence Similarities
Belongs to the adaptor complexes small subunit family.
Tissue Specificity
Present in all adult tissues examined.
Cellular localization
- Golgi apparatus
- Cytoplasmic vesicle membrane
- Peripheral membrane protein
- Cytoplasmic side
- Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
Alternative names
CLAPS3, AP3S1, AP-3 complex subunit sigma-1, AP-3 complex subunit sigma-3A, Adaptor-related protein complex 3 subunit sigma-1, Sigma-3A-adaptin, Sigma-adaptin 3a, Sigma3A-adaptin